You are viewing the site in preview mode
Skip to main content
| |
GIT-absorbed NP fraction after NP gavage [23]
|
Estimated NP fraction of GIT-absorption cleared from lungs
|
Ratio: GIT-absorb. NP over measured fractions after NP inhalation
|
|---|
|
2nd organs
|
24 h
|
7d
|
24 h
|
7d
|
24 h
|
7d
|
|---|
|
liver
|
1.27E-04
|
2.26E-05
|
1.21E-07
|
4.62E-08
|
4.53E-03
|
5.67E-03
|
|
spleen
|
3.19E-05
|
1.16E-05
|
1.68E-09
|
2.37E-09
|
2.50E-04
|
5.65E-04
|
|
kidneys
|
3.82E-05
|
2.30E-05
|
2.74E-08
|
3.19E-08
|
3.42E-03
|
3.86E-03
|
|
heart
|
7.96E-05
|
4.89E-06
|
2.78E-09
|
2.24E-10
|
1.66E-04
|
1.27E-04
|
|
brain
|
1.01E-05
|
2.38E-05
|
7.66E-11
|
1.12E-09
|
3.59E-05
|
1.31E-04
|
|
uterus
|
2.44E-05
|
4.37E-05
|
1.43E-09
|
3.61E-09
|
2.77E-04
|
2.29E-04
|
|
carcass
|
8.07E-04
|
2.88E-04
|
5.82E-06
|
4.51E-06
|
3.42E-02
|
4.34E-02
|
|
skeleton
|
4.39E-04
|
8.96E-04
|
1.87E-06
|
7.09E-06
|
2.02E-02
|
2.20E-02
|
|
soft tissue
|
4.58E-04
|
5.00E-06
|
1.40E-06
|
3.86E-08
|
1.45E-02
|
2.15E-02
|
- Mean values of GIT-absorbed fractions after [48V]TiO2-NP gavage in the left two columns at 24 h or 7 days were taken from [23]. Estimated contribution of GIT-absorption of [48V]TiO2-NP cleared from lungs were calculated by multiplying the mean values of [48V]TiO2-NP cleared after 24 h by MCC into the GIT and the sum of all [48V]TiO2-NP which had entered the GIT within the first 7 days p.e. (Table 2) and the fraction in the according left column of the Table 4. These are shown in the middle columns of Table 4. The ratios of GIT-absorbed [48V]TiO2-NP at 24 h or 7 days divided by the mean values of the measured organ or tissue fractions of Table 3 after [48V]TiO2-NP inhalation are presented in the right columns of Table 4. These ratios confirm the rather low contribution of GIT-absorbed [48V]TiO2-NP to the measured accumulation of each secondary organ or tissue in Table 3
