Articles

Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells

Nano- and microscale copper oxide particles (CuO NP, CuO MP) are applied for manifold purposes, enhancing exposure and thus the potential risk of adverse health effects. Based on the pronounced in vitro cytoto...

Authors: Bettina Maria Strauch, Rebecca Katharina Niemand, Nicola Lisa Winkelbeiner and Andrea Hartwig

Multi-walled carbon nanotubes-induced alterations in microRNA let-7 and its targets activate a protection mechanism by conferring a developmental timing control

Multi-walled carbon nanotubes (MWCNTs) have been produced and applied for diverse purposes. MWCNTs can potentially cause the adverse effects on organisms. MicroRNA let-7 and its targets of HBL-1 and LIN-41 play a...

Authors: Li Zhao, Hanxiao Wan, Qizhan Liu and Dayong Wang

STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes

Pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs) is influenced by physicochemical characteristics and genetic susceptibility. We hypothesized that contrasting rigidities of tangled (t) versus rod-l...

Authors: Katherine S. Duke, Alexia J. Taylor-Just, Mark D. Ihrie, Kelly A. Shipkowski, Elizabeth A. Thompson, Erinn C. Dandley, Gregory N. Parsons and James C. Bonner

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was ...

Authors: James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard…

A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop

Exposure to nanoparticles in the workplace is a health concern to occupational workers with increased risk of developing respiratory, cardiovascular, and neurological disorders. Based on animal inhalation stud...

Authors: Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen, Kiao Inthavong and Jiyuan Tu

Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. Generally less information is given on heal...

Authors: Daniela Schwotzer, Heinrich Ernst, Dirk Schaudien, Heiko Kock, Gerhard Pohlmann, Clemens Dasenbrock and Otto Creutzenberg

Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. The ECM provides essential physical scaffolding for the cellular constituent...

Authors: Ayse Basak Engin, Dragana Nikitovic, Monica Neagu, Petra Henrich-Noack, Anca Oana Docea, Mikhail I. Shtilman, Kirill Golokhvast and Aristidis M. Tsatsakis

MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica

Dendritic cells (DCs) are specialized first-line sensors of foreign materials invading the organism. These sentinel cells rely on pattern recognition receptors such as Nod-like or Toll-like receptors (TLRs) to...

Authors: Hans Christian Winkler, Julian Kornprobst, Peter Wick, Lea Maria von Moos, Ioannis Trantakis, Elisabeth Maria Schraner, Barbara Bathke, Hubertus Hochrein, Mark Suter and Hanspeter Naegeli

Programming of mouse obesity by maternal exposure to concentrated ambient fine particles

Many diseases including obesity may originate through alterations in the early-life environment that interrupts fetal development. Increasing evidence has shown that exposure to ambient fine particles (PM_2.5) is ...

Authors: Minjie Chen, Xiaoke Wang, Ziying Hu, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Xiaobo Qin, Yuhao Zhang and Zhekang Ying

Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

The death toll associated with inhaled ambient particulate matter (PM) is attributed mainly to cardio-vascular rather than pulmonary effects. However, it is unclear whether the key event for cardiovascular imp...

Authors: Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G. Kreyling, Holger Schulz, Otmar Schmid and Tobias Stoeger

Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation

Carbon nanotubes (CNTs) have been used in a variety of applications because of their unique properties and functions. However, many CNTs have been shown to induce lung fibrosis in experimental animals with som...

Authors: Jie Dong and Qiang Ma

Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

The use of multiwalled carbon nanotubes (MWCNT) is increasing due to a growing use in a variety of products across several industries. Thus, occupational exposure is also of increasing concern, particularly si...

Authors: H. K. L. Johansson, J. S. Hansen, B. Elfving, S. P. Lund, Z. O. Kyjovska, S. Loft, K. K. Barfod, P. Jackson, U. Vogel and K. S. Hougaard

Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome

Epidemiological studies have linked exposures to ambient fine particulate matter (PM_2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preex...

Authors: Alex P. Carll, Samir M. Crespo, Mauricio S. Filho, Douglas H. Zati, Brent A. Coull, Edgar A. Diaz, Rodrigo D. Raimundo, Thomas N. G. Jaeger, Ana Laura Ricci-Vitor, Vasileios Papapostolou, Joy E. Lawrence, David M. Garner, Brigham S. Perry, Jack R. Harkema and John J. Godleski

Impaired lysosomal activity mediated autophagic flux disruption by graphite carbon nanofibers induce apoptosis in human lung epithelial cells through oxidative stress and energetic impairment

Graphite carbon nanofibers (GCNF) have emerged as a potential alternative of carbon nanotubes (CNT) for various biomedical applications due to their superior physico-chemical properties. Therefore in-depth und...

Authors: Sandeep Mittal, Pradeep Kumar Sharma, Ratnakar Tiwari, Raja Gopal Rayavarapu, Jai Shankar, Lalit Kumar Singh Chauhan and Alok Kumar Pandey

Erratum to: In Memorian Thomas W. Hesterberg, PhD MBA (1950–2016)

Authors: David B. Warheit

Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation

The wide application of engineered nanoparticles has induced increasing exposure to humans and environment, which led to substantial concerns on their biosafety. Some metal oxides (MOx) have shown severe toxic...

Authors: Xiaoming Cai, Anson Lee, Zhaoxia Ji, Cynthia Huang, Chong Hyun Chang, Xiang Wang, Yu-Pei Liao, Tian Xia and Ruibin Li

In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation

Previous work has demonstrated size, surface charge and skin barrier dependent penetration of nanoparticles into the viable layers of mouse skin. The goal of this work was to characterize the tissue distributi...

Authors: Samreen Jatana, Brian C. Palmer, Sarah J. Phelan, Robert Gelein and Lisa A. DeLouise

SiO₂ and TiO₂ nanoparticles synergistically trigger macrophage inflammatory responses

Silicon dioxide (SiO₂) nanoparticles (NPs) and titanium dioxide (TiO₂) NPs are the most widely used inorganic nanomaterials. Although the individual toxicities of SiO₂ and TiO₂ NPs have been extensively studied, ...

Authors: Misato Tsugita, Nobuyuki Morimoto and Masafumi Nakayama

Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults

Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations ha...

Authors: Jenny Rissler, Anders Gudmundsson, Hanna Nicklasson, Erik Swietlicki, Per Wollmer and Jakob Löndahl

In Memorian Thomas W. Hesterberg, PhD MBA (1950 – 2016)

Authors: David B. Warheit

Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons

Carbon black nanoparticles (CBNP) are mainly composed of carbon, with a small amount of other elements (including hydrogen and oxygen). The toxicity of CBNP has been attributed to their large surface area, and...

Authors: Karina Lindner, Michael Ströbele, Sandra Schlick, Sina Webering, André Jenckel, Johannes Kopf, Olga Danov, Katherina Sewald, Christian Buj, Otto Creutzenberg, Thomas Tillmann, Gerhard Pohlmann, Heinrich Ernst, Christina Ziemann, Gereon Hüttmann, Holger Heine…

Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter

During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads in the ambient air. Among the environmental partic...

Authors: Sebastian G. Klein, Sébastien Cambier, Jennifer Hennen, Sylvain Legay, Tommaso Serchi, Inge Nelissen, Aline Chary, Elisa Moschini, Andreas Krein, Brunhilde Blömeke and Arno C. Gutleb

Particulate Air pollution mediated effects on insulin resistance in mice are independent of CCR2

Chronic exposure to fine ambient particulate matter (PM_2.5) induces insulin resistance. CC-chemokine receptor 2 (CCR2) appears to be essential in diet-induced insulin resistance implicating an important role for ...

Authors: Cuiqing Liu, Xiaohua Xu, Yuntao Bai, Jixin Zhong, Aixia Wang, Lixian Sun, Liya Kong, Zhekang Ying, Qinghua Sun and Sanjay Rajagopalan

Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles

Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertak...

Authors: Alison Buckley, James Warren, Alan Hodgson, Tim Marczylo, Konstantin Ignatyev, Chang Guo and Rachel Smith

Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle

Recent studies indicate that maternal exposure to ambient ultrafine particles and nanoparticles has adverse effects of on the central nervous system. Quantitative dose–response data is required to better under...

Authors: Atsuto Onoda, Ken Takeda and Masakazu Umezawa

Prenatal and postnatal mothering by diesel exhaust PM_2.5-exposed dams differentially program mouse energy metabolism

Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cau...

Authors: Minjie Chen, Shuai Liang, Huifen Zhou, Yanyi Xu, Xiaobo Qin, Ziying Hu, Xiaoke Wang, Lianglin Qiu, Wanjun Wang, Yuhao Zhang and Zhekang Ying

Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection

Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of ...

Authors: Christine Sattler, Franco Moritz, Shanze Chen, Beatrix Steer, David Kutschke, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Philippe Schmitt-Kopplin, Heiko Adler and Tobias Stoeger

In vitro biological responses to nanofibrillated cellulose by human dermal, lung and immune cells: surface chemistry aspect

Nanocellulose, and particularly nanofibrillated cellulose (NFC), has been proposed for a diversity of applications in industry and in the biomedical field. Its unique physicochemical and structural features di...

Authors: Viviana R. Lopes, Carla Sanchez-Martinez, Maria Strømme and Natalia Ferraz

Early kidney damage induced by subchronic exposure to PM_2.5 in rats

Particulate matter exposure is associated with respiratory and cardiovascular system dysfunction. Recently, we demonstrated that fine particles, also named PM_2.5, modify the expression of some components of the a...

Authors: O. G. Aztatzi-Aguilar, M. Uribe-Ramírez, J. Narváez-Morales, A. De Vizcaya-Ruiz and O. Barbier

Combined exposure of diesel exhaust particles and respirable Soufrière Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model

There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas alread...

Authors: Ines Tomašek, Claire J. Horwell, David E. Damby, Hana Barošová, Christoph Geers, Alke Petri-Fink, Barbara Rothen-Rutishauser and Martin J. D. Clift

Erratum to: Quantification of the cellular dose and characterization of nanoparticle transport during in vitro testing

Authors: Grigore Rischitor, Mariantonietta Parracino, Rita La Spina, Patricia Urbán, Isaac Ojea-Jiménez, Elena Bellido, Andrea Valsesia, Sabrina Gioria, Robin Capomaccio, Agnieszka Kinsner-Ovaskainen, Douglas Gilliland, François Rossi and Pascal Colpo

Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources

Industrial sources contribute a significant proportion of anthropogenic particulate matter (PM) emissions, producing particles of varying composition that may differentially impact health. This study investiga...

Authors: Errol M. Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Ngoc Q. Vuong, Ewa Dabek-Zlotorzynska, Valbona Celo, Jean-Pierre Charland, Prem Kumarathasan, Jeffrey R. Brook and Renaud Vincent

Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes

Deleterious consequences of exposure to traffic emissions may derive from interactions between carbonaceous particulate matter (PM) and gaseous components in a manner that is dependent on the surface area or c...

Authors: Christina R. Tyler, Katherine E. Zychowski, Bethany N. Sanchez, Valeria Rivero, Selita Lucas, Guy Herbert, June Liu, Hammad Irshad, Jacob D. McDonald, Barry E. Bleske and Matthew J. Campen

Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation

Nanotechnology developed rapidly in cellular diagnosis and treatment, the endocytic system was an important pathway for targeting cell. In the research of developing macrophages as drug carriers or important t...

Authors: Lin Xia, Weihong Gu, Mingyi Zhang, Ya-Nan Chang, Kui Chen, Xue Bai, Lai Yu, Juan Li, Shan Li and Gengmei Xing

Interaction of rat alveolar macrophages with dental composite dust

Dental composites have become the standard filling material to restore teeth, but during the placement of these restorations, high amounts of respirable composite dust (<5 μm) including many nano-sized particl...

Authors: K. L. Van Landuyt, S. M. Cokic, C. Asbach, P. Hoet, L. Godderis, F. X. Reichl, B. Van Meerbeek, A. Vennemann and M. Wiemann

Early signs of multi-walled carbon nanotbues degradation in macrophages, via an intracellular pH-dependent biological mechanism; importance of length and functionalization

Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages...

Authors: Marion Landry, Mathieu Pinault, Stéphane Tchankouo, Émeline Charon, Audrey Ridoux, Jorge Boczkowski, Martine Mayne-L’Hermite and Sophie Lanone

Myofibroblasts and lung fibrosis induced by carbon nanotube exposure

Carbon nanotubes (CNTs) are newly developed materials with unique properties and a range of industrial and commercial applications. A rapid expansion in the production of CNT materials may increase the risk of...

Authors: Jie Dong and Qiang Ma

Comment on Shvedova et al. (2016), “gender differences in murine pulmonary responses elicited by cellulose nanocrystals”

A recent publication in “Particle and Fibre Toxicology” reported on the gender differences in pulmonary toxicity from oro-pharyngeal aspiration of a high dose of cellulose nanocrystals. The study is timely giv...

Authors: Jo Anne Shatkin and Günter Oberdörster

Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

Recently, much progress has been made to develop more physiologic in vitro models of the respiratory system and improve in vitro simulation of particle exposure through inhalation. Nevertheless, the field of n...

Authors: Thomas Loret, Emmanuel Peyret, Marielle Dubreuil, Olivier Aguerre-Chariol, Christophe Bressot, Olivier le Bihan, Tanguy Amodeo, Bénédicte Trouiller, Anne Braun, Christophe Egles and Ghislaine Lacroix

Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms

Due to their unique physicochemical properties, graphene-family nanomaterials (GFNs) are widely used in many fields, especially in biomedical applications. Currently, many studies have investigated the biocomp...

Authors: Lingling Ou, Bin Song, Huimin Liang, Jia Liu, Xiaoli Feng, Bin Deng, Ting Sun and Longquan Shao

Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles

Copper nanoparticles (Cu NPs) have great potential in electronics and biomedical fields because of their efficient thermodynamic and anti-microbial properties. However, their potential toxic effects and kineti...

Authors: In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, In-Sik Shin, Changjong Moon, Je-Hein Kim, Hyoung-Chin Kim and Jong-Choon Kim

Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced b...

Authors: Haijun Liu, Shencun Fang, Wei Wang, Yusi Cheng, Yingming Zhang, Hong Liao, Honghong Yao and Jie Chao

Single- and double-walled carbon nanotubes enhance atherosclerogenesis by promoting monocyte adhesion to endothelial cells and endothelial progenitor cell dysfunction

The use of carbon nanotubes has increased lately. However, the cardiovascular effect of exposure to carbon nanotubes remains elusive. The present study investigated the effects of pulmonary exposure to single-...

Authors: Yuka Suzuki, Saeko Tada-Oikawa, Yasuhiko Hayashi, Kiyora Izuoka, Misa Kataoka, Shunsuke Ichikawa, Wenting Wu, Cai Zong, Gaku Ichihara and Sahoko Ichihara

Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

Multi-walled carbon nanotubes (MWCNTs) constitute one of the most promising types of nanomaterials in industry today. With their increasing use, the potential toxicity and carcinogenicity of MWCNT needs to be ...

Authors: Tatsuya Kasai, Yumi Umeda, Makoto Ohnishi, Takashi Mine, Hitomi Kondo, Tetsuya Takeuchi, Michiharu Matsumoto and Shoji Fukushima

The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of products, including rubber manufacture, cosmetics, pigments, food additives, medicine, chemical fibers and electronics. However, the molec...

Authors: Yuh-Feng Lin, I-Jen Chiu, Fong-Yu Cheng, Yu-Hsuan Lee, Ying-Jan Wang, Yung-Ho Hsu and Hui-Wen Chiu

The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases

The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these int...

Authors: Mutlay Sayan and Brooke T. Mossman

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays de...

Authors: John W. Wills, Nicole Hondow, Adam D. Thomas, Katherine E. Chapman, David Fish, Thierry G. Maffeis, Mark W. Penny, Richard A. Brown, Gareth J. S. Jenkins, Andy P. Brown, Paul A. White and Shareen H. Doak

Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

The rapidly increasing number of engineered nanoparticles (NPs), and products containing NPs, raises concerns for human exposure and safety. With this increasing, and ever changing, catalogue of NPs it is beco...

Authors: Matthew S. P. Boyles, Christina Ranninger, Roland Reischl, Marc Rurik, Richard Tessadri, Oliver Kohlbacher, Albert Duschl and Christian G. Huber

Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury

The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the abili...

Authors: Nathan A. Holland, Leslie C. Thompson, Achini K. Vidanapathirana, Rahkee N. Urankar, Robert M. Lust, Timothy R. Fennell and Christopher J. Wingard

Quantification of the cellular dose and characterization of nanoparticle transport during in vitro testing

The constant increase of the use of nanomaterials in consumer products is making increasingly urgent that standardized and reliable in vitro test methods for toxicity screening be made available to the scienti...

Authors: Grigore Rischitor, Mariantonietta Parracino, Rita La Spina, Patrizia Urbán, Isaac Ojea-Jiménez, Elena Bellido, Andrea Valsesia, Sabrina Gioria, Robin Capomaccio, Agnieszka Kinsner-Ovaskainen, Douglas Gilliland, François Rossi and Pascal Colpo